Brentwood is a district in western Los Angeles, California, United States; it should not be confused with Brentwood, California, in the San Francisco Bay Area of Northern California or the Brentwood area of Victorville, California.

Brentwood is located at the base of the Santa Monica Mountains, bounded by the San Diego Freeway on the east, Wilshire Boulevard on the south, the Santa Monica city limits on the southwest, the border of Topanga State Park on the west and Mulholland Drive along the ridgeline of the mountains on the north.

Nearby neighborhoods and cities include Pacific Palisades on the west, Santa Monica on the south, West Los Angeles and Sawtelle on the southeast, Westwood on the east, Bel-Air on the northeast and Encino on the north.

Mail to the Brentwood district is addressed, Los Angeles, CA 90049 to avoid confusion with the Bay Area municipality of Brentwood in Northern California.